Current Issue : January - March Volume : 2016 Issue Number : 1 Articles : 6 Articles
A sesquiterpene lactone 1-...
Buruli ulcer (BU) imposes a serious economic burden on affected households and on health systems that are involved in diagnosing\nthe disease and treating patients. Research is needed to find cost-effective therapies for this costly disease. Plants have always been\nan important source of new pharmacologically active molecules. Consequently we decided to undertake the study of plants used\nin traditional treatment of BU in Benin and investigate their antimycobacterial activity as well as their chemical composition.\nExtracts from forty-four (44) plant species were selected on account of reported traditional uses for the treatment of BU in Benin\nand were assayed for antimycobacterial activities. Crude hydroethanolic extract from aerial parts of Holarrhena floribunda (G.Don)\nT. Durand and Schinz was found to have significant antimycobacterial activity a gains M. ulcerans (MIC = 125 ...
An alternative to the use of chemical fungicides is to enhance the defensive response of plants by\nappropriate stimulation, a phenomenon known as induction of resistance. The aim of this study\nwas to determine the changes of endogen levels of salicylic acid (SA) and jasmonic acid (JA) in potato\nplants as response to foliar application of biotic and abiotic inductors. Treatments T1 = Best\nUltra F (Bacillus spp. 108 cfu/mL and Pseudomonas fluorescens 108 cfu/mL) 0.5%, T2 = FullKover\nHF (microbial jasmonic acid 1500 ppm) 0.2%, T3 = T1 0.5% + T2 0.1%, T4 = Milor�® (Chlorothalonil\n+ Metalaxyl) 0.5% and T5 = control (water) were applied in potato plants. The application of\nbiotic and abiotic inductors improved the SA and JA production in potato plants. The production of\nsalicylic acid in potato plants was observed by application of Bacillus spp. and Pseudomonas fluorescens\n(T1) and fungicide Milor�® (T4). The application of T1 Best Ultra F, T2 FullKover HF (microbial\nJA), T3 (T1 + T2) and T4 Milor�® improved the JA production in potato plants....
The purpose of the present work was to describe α amylase inhibition and antioxidant ability of three different seaweeds (Velaniopsis pachynema, Chnoospora minima, Gracilaria fergusonii) from Kanyakumari coast. These seaweeds are sequentially subjected to extraction using Methanol, Diethyl ether and Hexane. α Amylase inhibitors are used to control over hyperglycemia in type 2 diabetes mellitus also these inhibitors from natural sources can minimize the toxicity and side effects instead of using synthetic inhibitors to control hyperglycemia. The alpha amylase inhibition assay was carried out in only methanol extracts of seaweeds. The highest inhibition was recorded in Chnoospora minima (45 %, concentration of 50 µg/ml). Obviously, the antioxidant activity was determined by the scavenging assays. In the assay, high total phenol content was observed in methanol extract of Chnoospora minima (9.412±0.001 mg GAE/g) least in hexane extract of Velaniopsis pachynema (1.021±0.020 mg GAE/g). In total antioxidant activity the maximum level was observed in methanolic extract of Chnoospora minima (6.475±0.01 mg AAE /g) less in Velaniopsis pachynema (1.003±0.013 mg AAE /g). In FRAP assay the highest value recorded in Chnoospora minima (6.160±0.03%) and least value shown in Velaniopsis pachynema (0.924±0.05%). Among the seaweed extracts, the scavenging ability against hydrogen peroxide was highly shown in methanol extract of Chnoospora minima (7.003±0.03%) and fewer in Velaniopsis pachynema (0.962±0.01). The methanol extract of Chnoospora minima (4.082±0.05%) shown highest value against DPPH Scavenging assay and low value showed in Velaniopsis pachynema (0.831±0.01%) and the Deoxyribose scavenging assay methanol extract of Chnoospora minima shown high ability (6.275±0.01%) and less in (0.563±0.06%). Because of the polar nature the methanol extract shown high activity in all the assays and considering, hexane (non polar) shows least ability in the entire scavenging assay....
Aim of study: Curcuma zedoaria (Family: Zingiberaceae) is being used in traditional medicine for the treatment of severe\nbronchitis and asthma. So the aim of study was to evaluate antiasthmatic activity of extracts of curcuma zedoaria rhizomes\nto validate its traditional & Ethnopharmacological use.\nMaterials and methods: In the present study petroleum ether, ethanol and water extract of Curcuma zedoaria rhizomes at\nthe doses of 25-100 mg/kg i. p. was evaluated for antiasthmatic activity using milk induced eosinophilia in mice.\nResults: The results of present investigation showed that the ethanol extract of Curcuma zedoaria rhizomes at (25-100\nmg/kg, i.p.) significantly decreases milk induced eosinophilia in mice in a dose dependent manner when compared to\npetroleum ether, water extract and control group.\nConclusion: It can be concluded that the ethanol extract of Curcuma zedoaria (100 mg/kg) may be useful in management &\nprevention of asthma....
Introduction: Cinnamon is currently marketed as a remedy for obesity, glucose intolerance, diabetes mellitus and\ndyslipidaemia. Integrative medicine is a new concept that combines conventional treatment with evidence-based\ncomplementary therapies.\nAim: The aim of this review is to critically evaluate the experimental evidence available for cinnamon in improving\nglycaemic targets in animal models and humans.\nResults: Insulin receptor auto-phosphorlylation and de-phosphorylation, glucose transporter 4 (GLUT-4 ) receptor\nsynthesis and translocation, modulation of hepatic glucose metabolism through changes in Pyruvate kinase (PK)\nand Phosphenol Pyruvate Carboxikinase (PEPCK), altering the expression of PPAR (�³) and inhibition of intestinal\nglucosidases are some of the mechanisms responsible for improving glycaemic control with cinnamon therapy.\nWe reviewed 8 clinical trials that used Cinnamomum cassia in aqueous or powder form in doses ranging from\n500 mg to 6 g per day for a duration lasting from 40 days to 4 months as well as 2 clinical trials that used\ncinnamon on treatment na�¯ve patients with pre-diabetes. An improvement in glycaemic control was seen in\npatients who received Cinnamon as the sole therapy for diabetes, those with pre-diabetes (IFG or IGT) and in\nthose with high pre-treatment HbA1c. In animal models, cinnamon reduced fasting and postprandial plasma\nglucose and HbA1c.\nConclusion: Cinnamon has the potential to be a useful add-on therapy in the discipline of integrative medicine\nin managing type 2 diabetes. At present the evidence is inconclusive and long-term trials aiming to establish the\nefficacy and safety of cinnamon is needed. However, high coumarin content of Cinnamomum cassia is a concern,\nbut Cinnamomum zeylanicum with its low coumarin content would be a safer alternate....
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